CVM-1118 Clinical Development

CVM-1118

Scientific publications and clinical research supporting the development of CVM-1118.
Scientific Publications
01 / RESEARCH
Selected publications, clinical studies and scientific presentations related to CVM-1118 and vasculogenic mimicry.
2016
Tumor’s DIY Blood Vessels
Science 352:1381–1383
2016
Tumor cell vascular mimicry: Novel targeting opportunity in melanoma
Pharmacology & Therapeutics 159:83–92
2017
Phase I dose escalation study of CVM-1118, a novel anti-vascular mimicry agent, in patients with advanced cancers
ASCO Abstract 2580
2019
Vasculogenic Mimicry: Become an Endothelial Cell “But Not So Much”
Front Oncology 9:803
2023
CVM-1118 (foslinanib), A 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1
Pathol. Oncol. Res. 29:1611038
2023
CVM-1118: A potent oral anti-vasculogenic mimicry (VM) agent in patients with advanced neuroendocrine tumors (NETs)—A phase IIa study
ASCO Abstract e16235
2024
CVM-1118: An oral anti-vasculogenic mimicry (VM) agent in combination with Nivolumab in patients with unresectable advanced hepatocellular carcinoma (HCC)—a Phase IIa study
ASCO Abstract e16150
2024
An oral anti-vasculogenic mimicry (VM) agent in combination with Nivolumab in patients with unresectable advanced hepatocellular carcinoma (HCC)—a Phase IIa study
ASCO Breakthrough Poster #92
2024
CVM-005: Phase IIa study of CVM-1118, a novel oral anti-vasculogenic mimicry (VM) agent, in advanced neuroendocrine tumors (NET) after progression on prior therapy
ESMO Abstract #1145MO
2025
CVM-005: A multicenter, single-arm, phase IIa study of CVM-1118, a novel oral anti-vasculogenic mimicry (VM) agent, in patients with treatment-refractory advanced neuroendocrine tumors (NET)
ENETS Poster #E57
LATEST RESEARCH
2026
Dynamic 3D imaging system detects vasculogenic mimicry and screens inhibitors in EGFR-mutant lung cancer
Translational Research 296:122–137